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KMID : 0604520000260010081
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Journal of the Society of Cosmetic Scientists of Korea
2000 Volume.26 No. 1 p.81 ~ p.91
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Stabilization of Enzyme for Application to Cosmetic Products
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김무성
이동철/이성구/강병영/선보경/안수선/심영철
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Abstract
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Development of stabilized enzyme was attempted for cosmetic applications. Papain, a proteolytic enzyme, was stabilized through conjugation with a soluble carbohydrate biopolymer, SC-glucan^(TM). With a novel structure of the conjugation site, stability of the enzyme was significantly enhanced such that more than 90 % of the initial activity retained after a month storage at 45℃, while no activity were detected in native enzyme or enzyme simply mixed with SC-glucan^(TM) after the storage. Conjugation with SC-glucan^(TM) not only extended the half-life of the enzyme on storage at higher temperature, but was also found to protect enzymes against some components contained in cosmetic products for skin care. Cosmetic lotion containing 1 % papain conjugate was more effective and less irritative in exfoliating stratum corneum of human skin than the lotion containing 5% lactic acid, one of the current popular exfoliating agents.
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KEYWORD
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